Knowledge Center: Article

Endocrine disruption: Regulatory compliance

Minimizing risk in terms of endocrine disruptors

The endocrine system is a complex network that controls critical bodily functions like reproduction, immunity, metabolism and behaviour. Chemicals with endocrine-disrupting properties can interfere with the endocrine system in various ways, for example by mimicking natural hormones or blocking hormone receptors. Exposure to these chemicals may have a negative impact on both humans and the environment.

Possible impacts

There’s strong scientific evidence that a variety of chemicals can disrupt the endocrine systems of animals. But there’s limited evidence that exposure to chemicals can interfere with endocrine function in humans. Some studies have reported declines in human sperm over the last four decades. Increases in breast, prostate and testicular cancer have also been reported. These findings may be endocrine-related and have environmental causes, but the evidence is inconclusive. Nevertheless, there is little doubt that small disruptions in endocrine function, particularly during development, pregnancy and lactation, can lead to profound, long-term effects.

Legislative framework

Because of these developments, there’s increasing regulatory focus on endocrine disruptors (EDs). In 2018, the EU agreed on scientific criteria for the evaluation of EDs for the Plant Protection Products (PPP) Regulation and the Biocidal Products Regulation (BPR). Information requirements for EDs are also being developed for Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and a draft proposal is expected in 2022. Within these frameworks, several testing protocols are being developed and monitored.

Complying with changing regulations

So how can manufacturers and importers navigate this new and constantly evolving legislative landscape and comply with regulations? With over 50 years of experience, TRISKELION has extensive, up-to-date knowledge of PPP, BPR and REACH along with experience in testing for EDs. Our experts can help you by:

  • Thoroughly reviewing your current data and identifying any gaps
  • Conducting risk assessments and recommending courses of action
  • Advising on testing strategies and study plans
  • Contracting out research studies and monitoring
  • Performing detailed searches and assessments of available literature
  • Drafting expert statements and compiling reports for regulatory authorities

For all these services, you have a single, dedicated project manager as your point of contact to ensure streamlined communication and efficient handling of your case.

Do you want to minimize your risk in terms of endocrine disruptors? Please contact our business development team via +31 6 5280 3578.

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Do you want to minimize your risk in terms of endocrine disruptors?

Please contact our business development team via +31 6 5000 7475

How to navigate through changing legislation on endocrine disruptors

More information can be found in this two page in-depth publication (PDF).

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