Ligand binding assays (LBA) are still the golden standard for the quantitative analysis of therapeutic proteins and protein biomarkers in biological matrices. Alternatively, bioanalytical methods for proteins have been developed using liquid chromatography and mass spectrometry (LC-MS) after enzymatic digestion (bottom-up approach). Quantitative LC-MS analysis of intact proteins (MW>5 kDa) for bioanalytical purposes is still in its infant stage.
Bisphenol A is a high production volume compound and used to produce polymers. Since several years, there has been controversy about the safety of Bisphenol A, related to its application in food contact materials such as baby bottles. Consequently, human exposure to Bisphenol A has been investigated in a number of biomonitoring studies.
Evert Duistermaat of TNO Triskelion has won the ‘Alternatives to Animal Testing’ incentive award, which is granted annually by the Dutch Ministry of Economic Affairs. This year’s incentive award was given in recognition of research into the effects of inhaling substances.
Incentive award for ‘Alternatives to Animal testing’