To meet the rapidly growing global demand for protein, alternative protein sources are needed. For all protein sources it is necessary to know the quality of the protein we consume. FAO (2013) states that the preferred approach to measure protein quality is based on the DIAAS. This score determines which amino acid limits optimal growth and health, and at what level. However, FAO directs that the DIAAS should be investigated in humans or otherwise in pigs: expensive methods with ethical constraints. Is there an in vitro alternative?
To fulfill the demand for higher sensitivity and smaller sample size in bioanalysis, Triskelion is continuously working on the miniaturization of its methodologies. With regard to sample size, Triskelion typically applies 10 µl or 25 µl load volume of biological matrix after extensive optimization of the several sample preparation steps, which is sufficiently low for many bioanalytical applications.
The food and pharma industries are continuously developing novel products in relation to human health. A current topic is the worldwide problem of body weight management. Researchers are searching for products that influence satiation and satiety to control food intake and maintain a healthy body weight. The stomach plays a crucial role in initiating satiation and satiety due to its role of accommodating food and contributing to food intake regulation.
As part of oral drug development, reliable scientific data about the transit through the gastro-intestinal tract is needed, preferably in a time- and cost-efficient way. TNO Triskelion fulfils these requirements by offering gastro-intestinal testing with the TNO Triskelion gastroIntestinal Models (TIM). The TIM-1 and tiny-TIM systems simulate the dynamic conditions in the stomach and small intestine, whereas the TIM-2 system simulates the large intestine.