Research For better living

Product: Dermal absorption (OECD 427-428)

The dermal route is an important route-of-entry for many compounds, such as (agro)-chemicals, biocides and cosmetic ingredients so, subsequently. dermal absorption (DA) data need to be available for risk assessment purposes. Nowadays, in vitro DA data generated by using human skin are widely acceptable for use in risk assessment, although there discussion is still ongoing on how the generated data are, or should be, used in risk assessment. For cosmetic ingredients, due to the ban on animal testing, in vitro tests are the only option for generating dermal absorption data. At Triskelion, we have a long history in performing dermal absorption (DA) studies for the (agro)-chemical and cosmetic industry. Depending on your research question, both in vitro and in vivo studies can be performed and we will makes sure you choose the most appropriate study design. In vitro DA studies are routinely performed using human skin in flow-through diffusion cells (in-line cells, Permegear). Alternatively, static Franz cells can be used. In vivo studies are typically performed in rats. Depending on the identity of the compound and its expected metabolism, animals can be kept in glass metabolism cages to check for possible formation of CO2 or other volatiles.